mouse UBE2K Over-expression AAV
This is an AAV expressing Mouse Ube2k.
AAV-275481
AAV-m-UBE2K
Ready-to-use AAV expressing Mouse Ube2k (ubiquitin-conjugating enzyme E2K). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW492011; D5Ertd601e; E2-25k; HIP-2; Hip2; Hypg; Lig
Description (Vector)
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
Gene ID
53323
Gene Name (Vector)
ubiquitin-conjugating enzyme E2K
Gene Symbol
Ube2k
ORF Size (aa)
603
ORF Size (bp)
603 bp
RefSeq ID
NM_016786
RefSeq Synonyms
NM_016786, NM_001310619, NM_001310618, BC085311, BC002013,
Species
mouse
UniGene ID
Mm.441014
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.