mouse SGMS1 Over-expression AAV

Name 
AAV-m-SGMS1
Cat No 
AAV-271856
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Sgms1.

AAV-271856
AAV-m-SGMS1

Ready-to-use AAV expressing Mouse Sgms1 (sphingomyelin synthase 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
9530058O11Rik; AI841905; C80702; Mob; Sms1; Sor1; Tmem23
Description (Vector)
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth.
Gene ID
208449
Gene Name (Vector)
sphingomyelin synthase 1
Gene Symbol
Sgms1
ORF Size (aa)
1260
ORF Size (bp)
1260 bp
RefSeq ID
NM_144792
RefSeq Synonyms
NM_144792, NM_001168526, NM_001168525, BC085298, BC019443,
Species
mouse
UniGene ID
Mm.329810

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.