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mouse POLI Over-expression AAV

Name 
AAV-m-POLI
Cat No 
AAV-269018
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Poli.

AAV-269018
AAV-m-POLI

Ready-to-use AAV expressing Mouse Poli (polymerase (DNA directed), iota). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Rad30b
Description (Vector)
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Gene ID
26447
Gene Name (Vector)
polymerase (DNA directed), iota
Gene Symbol
Poli
ORF Size (aa)
2025
ORF Size (bp)
2025 bp
RefSeq ID
NM_011972
RefSeq Synonyms
NM_011972, NM_001289516, NM_001289515, NM_001136090, BC082278,
Species
mouse
UniGene ID
Mm.244352

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.