mouse IKBKG Over-expression AAV

Name 
AAV-m-IKBKG
Cat No 
AAV-262074
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Ikbkg.

AAV-262074
AAV-m-IKBKG

Ready-to-use AAV expressing Mouse Ikbkg (inhibitor of kappaB kinase gamma). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1110037D23Rik; AI848108; AI851264; AW124339; IKK[g]; NEMO
Description (Vector)
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity (By similarity). Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Gene ID
16151
Gene Name (Vector)
inhibitor of kappaB kinase gamma
Gene Symbol
Ikbkg
ORF Size (aa)
1236
ORF Size (bp)
1236 bp
RefSeq ID
NM_010547
RefSeq Synonyms
NM_178590, NM_010547, NM_001161424, NM_001161423, NM_001161422, NM_001161421, NM_001136067, BC021431,
Species
mouse
UniGene ID
Mm.12967

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.