mouse NEDD4L Over-expression AAV

Name 
AAV-m-NEDD4L
Cat No 
AAV-265629
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Nedd4l.

AAV-265629
AAV-m-NEDD4L

Ready-to-use AAV expressing Mouse Nedd4l (neural precursor cell expressed, developmentally down-regulated gene 4-like). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1300012C07Rik; Nedd4-2; Nedd4b
Description (Vector)
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.
Gene ID
83814
Gene Name (Vector)
neural precursor cell expressed, developmentally down-regulated gene 4-like
Gene Symbol
Nedd4l
ORF Size (aa)
2568
ORF Size (bp)
2568 bp
RefSeq ID
NM_031881
RefSeq Synonyms
NM_031881, NM_001114386, BC071210, BC039746,
Species
mouse
UniGene ID
Mm.98668

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.