mouse ICOS Over-expression AAV

Name 
AAV-m-ICOS
Cat No 
AAV-261832
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Icos.

AAV-261832
AAV-m-ICOS

Ready-to-use AAV expressing Mouse Icos (inducible T cell co-stimulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AILIM; CCLP; CRP-1; H4; Ly115
Description (Vector)
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Gene ID
54167
Gene Name (Vector)
inducible T cell co-stimulator
Gene Symbol
Icos
ORF Size (aa)
603
ORF Size (bp)
603 bp
RefSeq ID
NM_017480
RefSeq Synonyms
NM_017480, BC034852,
Species
mouse
UniGene ID
Mm.42044

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.