mouse NPHP1 Over-expression AAV

Name 
AAV-m-NPHP1
Cat No 
AAV-265982
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Nphp1.

AAV-265982
AAV-m-NPHP1

Ready-to-use AAV expressing Mouse Nphp1 (nephronophthisis 1 (juvenile) homolog (human)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Description (Vector)
Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity).
Gene ID
53885
Gene Name (Vector)
nephronophthisis 1 (juvenile) homolog (human)
Gene Symbol
Nphp1
ORF Size (aa)
2058
ORF Size (bp)
2058 bp
RefSeq ID
NM_016902
RefSeq Synonyms
NM_016902, NM_001291013, NM_001291012, BC118953,
Species
mouse
UniGene ID
Mm.477771

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.