mouse TDG Over-expression AAV

Name 
AAV-m-TDG
Cat No 
AAV-258408
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Tdg.

AAV-258408
AAV-m-TDG

Ready-to-use AAV expressing Mouse Tdg (thymine DNA glycosylase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
E130317C12Rik; JZA-3; Jza1
Description (Vector)
In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
Gene ID
21665
Gene Name (Vector)
thymine DNA glycosylase
Gene Symbol
Tdg
ORF Size (aa)
1266
ORF Size (bp)
1266 bp
RefSeq ID
NM_172552
RefSeq Synonyms
NM_172552, NM_011561, BC085471, BC085470, BC010315,
Species
mouse
UniGene ID
Mm.284252

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.