mouse ARHGEF4 Over-expression AAV
This is an AAV expressing Mouse Arhgef4.
AAV-252978
AAV-m-ARHGEF4
Ready-to-use AAV expressing Mouse Arhgef4 (Rho guanine nucleotide exchange factor (GEF) 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9330140K16Rik; Asef; ENSMUSG00000070955
Description (Vector)
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Gene ID
226970
Gene Name (Vector)
Rho guanine nucleotide exchange factor (GEF) 4
Gene Symbol
Arhgef4
ORF Size (aa)
1455
ORF Size (bp)
1455 bp
RefSeq ID
NM_183019
RefSeq Synonyms
NM_183019, BC139397, BC139371,
Species
mouse
UniGene ID
Mm.41604
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.