human RC3H2 Over-expression AAV

Name
AAV-h-RC3H2

Cat No
AAV-234397

Availability
4-5 weeks

This is an AAV expressing Human RC3H2.

AAV-234397

AAV-h-RC3H2

Ready-to-use AAV expressing Human RC3H2 (ring finger and CCCH-type domains 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

membrane associated DNA binding protein; membrane-associated nucleic acid-binding protein; MNAB; ring finger and CCCH-type zinc finger domain-containing protein 2; ring finger and CCCH-type zinc finger domains 2; RING finger protein 164; RING-type E3 ubiquitin transferase Roquin-2; RNF164; roquin-2

Description (eCommerce)

Roquin-2 is encoded by the gene RC3H2, also known as MNAB. Roquin-2 is a post-transcriptional repressor of mRNAs containing a conserved stem loop motif called the constitutive decay element (CDE). Binding to the CDE promotes mRNA deadenylation and degradation [taken from UniProtKB (Entry: Q9HBD1)].

Gene ID

54542

Gene Name (eCommerce)

ring finger and CCCH-type domains 2

Gene Name (Vector)

ring finger and CCCH-type domains 2

Gene Symbol

RC3H2

HGNC ID

HGNC:21461

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1521

ORF Size (bp)

1521 bp

Protein Name (eCommerce)

Roquin-2

RefSeq ID

NM_018835

RefSeq Synonyms

NM_018835, NM_001100588, BC044642,

Research Areas

RNA Binding,Zinc-finger

Research Areas (Faceted)

cell_biology

Species

human

Target Sentence

Roquin-2 is encoded by the gene RC3H2, also known as MNAB. Roquin-2 is a post-transcriptional repressor of mRNAs containing a conserved stem loop motif called the constitutive decay element (CDE). Binding to the CDE promotes mRNA deadenylation and degradation [taken from UniProtKB (Entry: Q9HBD1)].

UniProt ID (eCommerce)

Q9HBD1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.