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human KIR2DL5B Over-expression AAV

Name 
AAV-h-KIR2DL5B
Cat No 
AAV-232114
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human KIR2DL5B.

AAV-232114
AAV-h-KIR2DL5B

Ready-to-use AAV expressing Human KIR2DL5B (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
KIR2DL5; KIR2DL5.2; KIR2DLX
Description (Vector)
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Gene ID
553128
Gene Name (Vector)
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B
Gene Symbol
KIR2DL5B
HGNC ID
HGNC:16346
ORF Size (aa)
1128
ORF Size (bp)
1128 bp
RefSeq ID
NM_001018081
RefSeq Synonyms
NM_001018081, BC156860,
Species
human
UniGene ID
Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.