human SPTY2D1 Over-expression AAV

Name 
AAV-h-SPTY2D1
Cat No 
AAV-231642
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SPTY2D1.

AAV-231642
AAV-h-SPTY2D1

Ready-to-use AAV expressing Human SPTY2D1 (SPT2 chromatin protein domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Protein KU002155; protein SPT2 homolog; Spt2; SPT2 domain-containing protein 1; SPT2, Suppressor of Ty, domain containing 1
Description (eCommerce)
SPT2, Suppressor of Ty (SPTY2D1) is a histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). It is required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). SPTY2D1 binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). It facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). SPTY2D1 modulates RNA polymerase 1-mediated transcription (By similarity) and binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q68D10].
Gene ID
144108
Gene Name (eCommerce)
SPT2 chromatin protein domain containing 1
Gene Name (Vector)
SPT2 chromatin protein domain containing 1
Gene Symbol
SPTY2D1
HGNC ID
HGNC:26818
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1056
ORF Size (bp)
1056 bp
Protein Name (eCommerce)
Protein SPT2 homolog
RefSeq ID
NM_194285
RefSeq Synonyms
NM_194285, BC056261,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
SPT2, Suppressor of Ty (SPTY2D1) is a histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). It is required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). SPTY2D1 binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). It facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). SPTY2D1 modulates RNA polymerase 1-mediated transcription (By similarity) and binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q68D10].
UniGene ID
Hs.719399
UniProt ID (eCommerce)
Q68D10

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.