human RNF139 Over-expression AAV

Name 
AAV-h-RNF139
Cat No 
AAV-230802
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RNF139.

AAV-230802
AAV-h-RNF139

Ready-to-use AAV expressing Human RNF139 (ring finger protein 139). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HRCA1; RCA1; TRC8
Description (Vector)
RNF139 is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
Gene ID
11236
Gene Name (Vector)
ring finger protein 139
Gene Symbol
RNF139
HGNC ID
HGNC:17023
ORF Size (aa)
1995
ORF Size (bp)
1995 bp
RefSeq ID
NM_007218
RefSeq Synonyms
NM_007218, BC064636, BC021571,
Species
human
UniGene ID
Hs.492751

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.