human MAN2B1 Over-expression AAV

Name 
AAV-h-MAN2B1
Cat No 
AAV-230209
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MAN2B1.

AAV-230209
AAV-h-MAN2B1

Ready-to-use AAV expressing Human MAN2B1 (mannosidase alpha class 2B member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LAMAN; MANB
Description (Vector)
MAN2B1 encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
4125
Gene Name (Vector)
mannosidase alpha class 2B member 1
Gene Symbol
MAN2B1
HGNC ID
HGNC:6826
ORF Size (aa)
3036
ORF Size (bp)
3036 bp
RefSeq ID
NM_000528
RefSeq Synonyms
NM_001173498, NM_000528, BC000736,
Species
human
UniGene ID
Hs.356769

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.