human SRGAP1 Over-expression AAV

Name 
AAV-h-SRGAP1
Cat No 
AAV-229157
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SRGAP1.

AAV-229157
AAV-h-SRGAP1

Ready-to-use AAV expressing Human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ARHGAP13; NMTC2; rho GTPase-activating protein 13; SLIT-ROBO Rho GTPase-activating protein 1; srGAP1
Description (eCommerce)
SRGAP1/ARHGAP13 is a member of the srGAP family of proteins that contain a RhoGAP domain, an SH3 domain, and a Fes/CIP4 homology domain and interact with the intracellular domain of roundabout 1 (Robo1). Robo1 is the receptor for Slit signaling and is involved in neuronal cell migration and axon tract positioning. SRGAP1/ARHGAP13 functions to bind and decrease the level of active Cdc42 and RhoA small GTPases during Slit-Robo signaling.
Gene ID
57522
Gene Name (eCommerce)
SLIT-ROBO Rho GTPase activating protein 1
Gene Name (Vector)
SLIT-ROBO Rho GTPase activating protein 1
Gene Symbol
SRGAP1
HGNC ID
HGNC:17382
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3258
ORF Size (bp)
3258 bp
Protein Name (eCommerce)
SLIT-ROBO Rho GTPase-activating protein 1
RefSeq ID
NM_020762
RefSeq Synonyms
NM_020762, NM_001346201, BC053903, BC029919,
Research Areas
Axon Guidance,Neurobiology,Rho Signaling,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology
Species
human
Target Sentence
SRGAP1/ARHGAP13 is a member of the srGAP family of proteins that contain a RhoGAP domain, an SH3 domain, and a Fes/CIP4 homology domain and interact with the intracellular domain of roundabout 1 (Robo1). Robo1 is the receptor for Slit signaling and is involved in neuronal cell migration and axon tract positioning. SRGAP1/ARHGAP13 functions to bind and decrease the level of active Cdc42 and RhoA small GTPases during Slit-Robo signaling.
UniGene ID
Hs.210751
UniProt ID (eCommerce)
Q7Z6B7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.