human WWP1 Over-expression AAV

Name 
AAV-h-WWP1
Cat No 
AAV-227858
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human WWP1.

AAV-227858
AAV-h-WWP1

Ready-to-use AAV expressing Human WWP1 (WW domain containing E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AIP5; atrophin-1 interacting protein 5; Atrophin-1-interacting protein 5; HECT-type E3 ubiquitin transferase WWP1; hSDRP1; NEDD4-like E3 ubiquitin-protein ligase WWP1; Nedd-4-like ubiquitin-protein ligase; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1
Description (eCommerce)
WW domain-containing protein 1 (WWP1) functions as an E3 ubiquitin-protein ligase. WWP1 ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. WWP1 also ubiquitinates and promotes degradation of TGFBR1; TGFBR1 ubiquitination is enhanced by SMAD7, and WWP1 also ubiquitinates SMAD7 as well as SMAD6. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H0M0].
Description (Vector)
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.
Gene ID
11059
Gene Name (eCommerce)
WW domain containing E3 ubiquitin protein ligase 1
Gene Name (Vector)
WW domain containing E3 ubiquitin protein ligase 1
Gene Symbol
WWP1
HGNC ID
HGNC:17004
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2769
ORF Size (bp)
2769 bp
Protein Name (eCommerce)
NEDD4-like E3 ubiquitin-protein ligase WWP1
RefSeq ID
NM_007013
RefSeq Synonyms
NM_007013, BC036065,
Research Areas
Antigen Processing and Presentation,Host-Virus Interactions,Immunology,Neurobiology,Neurodevelopment,Signal Transduction,TGF-beta Signaling,Ubiquitination
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
WW domain-containing protein 1 (WWP1) functions as an E3 ubiquitin-protein ligase. WWP1 ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. WWP1 also ubiquitinates and promotes degradation of TGFBR1; TGFBR1 ubiquitination is enhanced by SMAD7, and WWP1 also ubiquitinates SMAD7 as well as SMAD6. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H0M0].
UniGene ID
Hs.655189
UniProt ID (eCommerce)
Q9H0M0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.