mouse WWP1 shRNA silencing AAV

Name
AAV-m-WWP1-shRNA

Cat No
shAAV-276353

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Wwp1.

shAAV-276353

AAV-m-WWP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Wwp1 (WW domain containing E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

8030445B08Rik; AIP5; SDRP1; Tiul1

Description (Vector)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Gene ID

107568

Gene Name (Vector)

WW domain containing E3 ubiquitin protein ligase 1

Gene Symbol

Wwp1

ORF Size (aa)

2757

ORF Size (bp)

2757 bp

RefSeq ID

NM_177327

RefSeq Synonyms

NM_177327, NM_001276292, BC150812, BC026829,

Species

mouse

UniGene ID

Mm.78312

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.