human USP2 Over-expression AAV

Name 
AAV-h-USP2
Cat No 
AAV-227292
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human USP2.

AAV-227292
AAV-h-USP2

Ready-to-use AAV expressing Human USP2 (ubiquitin specific peptidase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
UBP41; USP9
Description (Vector)
USP2 encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
9099
Gene Name (Vector)
ubiquitin specific peptidase 2
Gene Symbol
USP2
HGNC ID
HGNC:12618
ORF Size (aa)
1089
RefSeq ID
NM_004205
RefSeq Synonyms
NM_171997, NM_004205, NM_001243759, BC041366, BC002955, BC002854,
Species
human
UniGene ID
Hs.524085

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.