human UHRF2 Over-expression AAV

Name
AAV-h-UHRF2

Cat No
AAV-227166

Availability
4-5 weeks

This is an AAV expressing Human UHRF2.

AAV-227166

AAV-h-UHRF2

Ready-to-use AAV expressing Human UHRF2 (ubiquitin like with PHD and ring finger domains 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NIRF; RNF107; TDRD23; URF2

Description (Vector)

UHRF2 encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

Gene ID

115426

Gene Name (Vector)

ubiquitin like with PHD and ring finger domains 2

Gene Symbol

UHRF2

HGNC ID

HGNC:12557

ORF Size (aa)

1512

ORF Size (bp)

1512 bp

RefSeq ID

NM_152896

RefSeq Synonyms

NM_152896, BC028397,

Species

human

UniGene ID

Hs.493401

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.