human TTF1 Over-expression AAV

Name 
AAV-h-TTF1
Cat No 
AAV-226734
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TTF1.

AAV-226734
AAV-h-TTF1

Ready-to-use AAV expressing Human TTF1 (transcription termination factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
RNA polymerase I termination factor; transcription termination factor 1; Transcription termination factor I; transcription termination factor, RNA polymerase I; TTF-1; TTF-I
Description (eCommerce)
Transcription termination factor (TTF1) is a multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest, and regulates RNA polymerase I transcription on chromatin. TTF1 plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. TTF1 has been shown to interact with BAZ2A/TIP5. An Interaction with BAZ2A/TIP5 recovers DNA-binding activity. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96RN5].
Description (Vector)
TTF1 encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. TTF1 shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.
Gene ID
7270
Gene Name (eCommerce)
transcription termination factor 1
Gene Name (Vector)
transcription termination factor 1
Gene Symbol
TTF1
HGNC ID
HGNC:12397
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2718
ORF Size (bp)
2718 bp
Protein Name (eCommerce)
Transcription termination factor 1
RefSeq ID
NM_007344
RefSeq Synonyms
NM_007344, NM_001205296, BC167784,
Research Areas
Chromatin Remodeling,DNA Replication,Epigenetic Regulation of Gene Expression,Gene Expression,Signal Transduction,Transcription Factor/Regulator,TSH Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,genetics,transcription_translation,signal_transduction
Species
human
Target Sentence
Transcription termination factor (TTF1) is a multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest, and regulates RNA polymerase I transcription on chromatin. TTF1 plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. TTF1 has been shown to interact with BAZ2A/TIP5. An Interaction with BAZ2A/TIP5 recovers DNA-binding activity. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96RN5].
UniGene ID
Hs.54780
UniProt ID (eCommerce)
Q15361

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.