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human TTF1 shRNA silencing Adenovirus

Name 
Ad-h-TTF1-shRNA
Cat No 
shADV-226734
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TTF1.

shADV-226734
Ad-h-TTF1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TTF1 (transcription termination factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
RNA polymerase I termination factor; transcription termination factor 1; Transcription termination factor I; transcription termination factor, RNA polymerase I; TTF-1; TTF-I
Description (eCommerce)
Transcription termination factor (TTF1) is a multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest, and regulates RNA polymerase I transcription on chromatin. TTF1 plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. TTF1 has been shown to interact with BAZ2A/TIP5. An Interaction with BAZ2A/TIP5 recovers DNA-binding activity. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96RN5].
Description (Vector)
TTF1 encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. TTF1 shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.
Gene ID
7270
Gene Name (eCommerce)
transcription termination factor 1
Gene Name (Vector)
transcription termination factor 1
Gene Symbol
TTF1
HGNC ID
HGNC:12397
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2718
ORF Size (bp)
2718 bp
Protein Name (eCommerce)
Transcription termination factor 1
RefSeq ID
NM_007344
RefSeq Synonyms
NM_007344, NM_001205296, BC167784,
Research Areas
Chromatin Remodeling,DNA Replication,Epigenetic Regulation of Gene Expression,Gene Expression,Signal Transduction,Transcription Factor/Regulator,TSH Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,genetics,transcription_translation,signal_transduction
Species
human
Target Sentence
Transcription termination factor (TTF1) is a multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest, and regulates RNA polymerase I transcription on chromatin. TTF1 plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. TTF1 has been shown to interact with BAZ2A/TIP5. An Interaction with BAZ2A/TIP5 recovers DNA-binding activity. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96RN5].
UniGene ID
Hs.54780
UniProt ID (eCommerce)
Q15361

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.