human TSPYL2 Over-expression AAV

Name 
AAV-h-TSPYL2
Cat No 
AAV-226659
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TSPYL2.

AAV-226659
AAV-h-TSPYL2

Ready-to-use AAV expressing Human TSPYL2 (TSPY like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CASK-interacting nucleosome assembly protein; CDA1; cell division autoantigen 1; CINAP; CTCL; CTCL tumor antigen se20-4; CTCL-associated antigen se20-4; cutaneous T-cell lymphoma-associated antigen se20-4; cutaneous T-cell lymphoma-associated tumor antigen se20-4; DENTT; differentially expressed nucleolar TGF-beta1 target; differentially-expressed nucleolar TGF-beta1 target protein; HRIHFB2216; NP79; nuclear protein of 79 kDa; SE204; testis-specific protein Y encoded-like 2; testis-specific Y-encoded-like protein 2; TSPX; TSPY-like protein 2
Description (eCommerce)
Differentially-expressed nucleolar TGF-beta1 target protein (DENTT) is part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. DENTT may inhibit cell proliferation by inducing p53-dependent CDKN1A expression [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2G4].
Description (Vector)
TSPYL2 encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth.
Gene ID
64061
Gene Name (eCommerce)
TSPY like 2
Gene Name (Vector)
TSPY like 2
Gene Symbol
TSPYL2
HGNC ID
HGNC:24358
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2082
ORF Size (bp)
2082 bp
Protein Name (eCommerce)
Testis-specific Y-encoded-like protein 2
RefSeq ID
NM_022117
RefSeq Synonyms
NM_022117, BC024270,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Replication,Replication,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Differentially-expressed nucleolar TGF-beta1 target protein (DENTT) is part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. DENTT may inhibit cell proliferation by inducing p53-dependent CDKN1A expression [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2G4].
UniGene ID
Hs.136164
UniProt ID (eCommerce)
Q9H2G4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.