human TRPC6 Over-expression AAV

Name 
AAV-h-TRPC6
Cat No 
AAV-226546
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TRPC6.

AAV-226546
AAV-h-TRPC6

Ready-to-use AAV expressing Human TRPC6 (transient receptor potential cation channel subfamily C member 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
focal segmental glomerulosclerosis 2; FSGS2; short transient receptor potential channel 6; transient receptor protein 6; TRP6; TRP-6; TrpC6
Description (eCommerce)
TRPC6 (transient receptor potential cation channel, subfamily C, member 6) forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in the TRPC6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) [taken from NCBI Entrez Gene (Gene ID: 7225].
Description (Vector)
TRPC6 forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Gene ID
7225
Gene Name (eCommerce)
transient receptor potential cation channel subfamily C member 6
Gene Name (Vector)
transient receptor potential cation channel subfamily C member 6
Gene Symbol
TRPC6
HGNC ID
HGNC:12338
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2796
ORF Size (bp)
2796 bp
Protein Name (eCommerce)
Short transient receptor potential channel 6
RefSeq ID
NM_004621
RefSeq Synonyms
NM_004621, BC093660, BC093658,
Research Areas
Axon Guidance,Cardiovascular,GPCR Signaling,Neurobiology,Signal Transduction,Transport
Research Areas (Faceted)
cardiovascular,signal_transduction,neurobiology,neurobiology,cell_biology
Species
human
Target Sentence
TRPC6 (transient receptor potential cation channel, subfamily C, member 6) forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in the TRPC6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) [taken from NCBI Entrez Gene (Gene ID: 7225].
UniGene ID
Hs.159003
UniProt ID (eCommerce)
Q9Y210

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.