human TNNC1 Over-expression AAV

Name 
AAV-h-TNNC1
Cat No 
AAV-226127
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TNNC1.

AAV-226127
AAV-h-TNNC1

Ready-to-use AAV expressing Human TNNC1 (troponin C1, slow skeletal and cardiac type). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CMD1Z; CMH13; TN-C; TNC; TNNC
Description (Vector)
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.
Gene ID
7134
Gene Name (Vector)
troponin C1, slow skeletal and cardiac type
Gene Symbol
TNNC1
HGNC ID
HGNC:11943
ORF Size (aa)
486
RefSeq ID
NM_003280
RefSeq Synonyms
NM_003280, BC030244,
Species
human
UniGene ID
Hs.118845

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.