human TLE2 Over-expression AAV

Name 
AAV-h-TLE2
Cat No 
AAV-225564
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human TLE2.

AAV-225564
AAV-h-TLE2

Ready-to-use AAV expressing Human TLE2 (transducin like enhancer of split 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
enhancer of split groucho-like protein 2; ESG; ESG2; GRG2; transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 2, homolog of Drosophila E(sp1); transducin-like enhancer protein 2
Description (eCommerce)
Transducin-like enhancer protein 2 (TLE2) transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q04725].
Gene ID
7089
Gene Name (eCommerce)
transducin like enhancer of split 2
Gene Name (Vector)
transducin like enhancer of split 2
Gene Symbol
TLE2
HGNC ID
HGNC:11838
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2232
ORF Size (bp)
2232 bp
Protein Name (eCommerce)
Transducin-like enhancer protein 2
RefSeq ID
NM_003260
RefSeq Synonyms
NM_003260, NM_001300846, NM_001144762, NM_001144761, BC017364,
Research Areas
Cancer,Notch Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Transducin-like enhancer protein 2 (TLE2) transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q04725].
UniGene ID
Hs.332173
UniProt ID (eCommerce)
Q04725

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.