human SUZ12 Over-expression AAV

Name 
AAV-h-SUZ12
Cat No 
AAV-224778
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SUZ12.

AAV-224778
AAV-h-SUZ12

Ready-to-use AAV expressing Human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
chET 9 protein; CHET9; chromatin precipitated E2F target 9 protein; JJAZ1; joined to JAZF1 protein; polycomb protein SUZ12; suppressor of zeste 12 protein homolog
Description (eCommerce)
SUZ12 (suppressor of zeste 12) is the human homolog of the drosophila SUZ12 gene. SUZ12 is a Polycomb group (PcG) protein and a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. A chromosomal aberration, t(7;17)(p15;q21), involving SUZ12 and JAZF1 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15022].
Description (Vector)
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Gene ID
23512
Gene Name (eCommerce)
SUZ12, polycomb repressive complex 2 subunit
Gene Name (Vector)
SUZ12 polycomb repressive complex 2 subunit
Gene Symbol
SUZ12
HGNC ID
HGNC:17101
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2220
ORF Size (bp)
2220 bp
Protein Name (eCommerce)
Polycomb protein SUZ12
RefSeq ID
NM_015355
RefSeq Synonyms
NM_015355, NM_001321207, BC015704,
Research Areas
Cancer,Chromatin Remodeling,Complexome,Epigenetic Regulation of Gene Expression,Histone Modification,Polycomb Proteins,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
SUZ12 (suppressor of zeste 12) is the human homolog of the drosophila SUZ12 gene. SUZ12 is a Polycomb group (PcG) protein and a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. A chromosomal aberration, t(7;17)(p15;q21), involving SUZ12 and JAZF1 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15022].
UniGene ID
Hs.462732
UniProt ID (eCommerce)
Q15022

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.