human SUCLA2 Over-expression AAV

Name 
AAV-h-SUCLA2
Cat No 
AAV-224692
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SUCLA2.

AAV-224692
AAV-h-SUCLA2

Ready-to-use AAV expressing Human SUCLA2 (succinate-CoA ligase ADP-forming beta subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A-BETA; A-SCS; ATP-specific succinyl-CoA synthetase subunit beta; ATP-specific succinyl-CoA synthetase, beta subunit; mitochondrial succinyl-CoA ligase ADP-forming subunit beta; MTDPS5; renal carcinoma antigen NY-REN-39; SCS-betaA; succinate--CoA ligase ADP-forming subunit beta, mitochondrial; succinate-CoA ligase beta subunit; succinyl-CoA ligase ADP-forming subunit beta, mitochondrial; succinyl-CoA synthetase beta-A chain
Description (eCommerce)
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. SUCLA2 is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA [taken from NCBI Entrez Gene (Gene ID: 8803)].
Description (Vector)
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.
Gene ID
8803
Gene Name (eCommerce)
succinate-CoA ligase ADP-forming beta subunit
Gene Name (Vector)
succinate-CoA ligase ADP-forming beta subunit
Gene Symbol
SUCLA2
HGNC ID
HGNC:11448
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1392
ORF Size (bp)
1392 bp
Protein Name (eCommerce)
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
RefSeq ID
NM_003850
RefSeq Synonyms
NM_003850, BC027587,
Research Areas
Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. SUCLA2 is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA [taken from NCBI Entrez Gene (Gene ID: 8803)].
UniGene ID
Hs.546323
UniProt ID (eCommerce)
Q9P2R7

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.