human STUB1 Over-expression AAV

Name 
AAV-h-STUB1
Cat No 
AAV-224646
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human STUB1.

AAV-224646
AAV-h-STUB1

Ready-to-use AAV expressing Human STUB1 (STIP1 homology and U-box containing protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
antigen NY-CO-7; carboxy terminus of Hsp70-interacting protein; CHIP; CLL-associated antigen KW-8; E3 ubiquitin-protein ligase CHIP; heat shock protein A binding protein 2 (c-terminal); HSPABP2; NY-CO-7; RING-type E3 ubiquitin transferase CHIP; SCAR16; SDCCAG7; serologically defined colon cancer antigen 7; STIP1 homology and U box-containing protein 1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; UBOX1
Description (eCommerce)
STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53.
Description (Vector)
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 (PubMed 18411298)).(supplied by OMIM, Jul 2009)
Gene ID
10273
Gene Name (eCommerce)
STIP1 homology and U-box containing protein 1
Gene Name (Vector)
STIP1 homology and U-box containing protein 1
Gene Symbol
STUB1
HGNC ID
HGNC:11427
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
912
Protein Name (eCommerce)
E3 ubiquitin-protein ligase CHIP
RefSeq ID
NM_005861
RefSeq Synonyms
NM_005861, NM_001293197, BC063617, BC022788, BC017178, BC007545,
Research Areas
Aging,Antigen Processing and Presentation,DNA Damage/Repair,Immunology,Neurobiology,Neurodegeneration,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Signal Transduction,TGF-beta Signaling,Ubiquitination
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53.
UniGene ID
Hs.592081
UniProt ID (eCommerce)
Q9UNE7

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.