human STK24 Over-expression AAV

Name 
AAV-h-STK24
Cat No 
AAV-224584
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human STK24.

AAV-224584
AAV-h-STK24

Ready-to-use AAV expressing Human STK24 (serine/threonine kinase 24). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
epididymis secretory protein Li 95; HEL-S-95; mammalian STE20-like protein kinase 3; MST3; MST-3; MST3B; serine/threonine kinase 24 (STE20 homolog, yeast); serine/threonine-protein kinase 24; STE20; STE20-like kinase 3; STE20-like kinase MST3; sterile 20-like kinase 3; STK3
Description (eCommerce)
MST3/STK24 is a member of the sterile 20 (Ste20)-like kinase family that acts upstream of mitogen-activated protein kinase (MAPK) pathways and regulates c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). Ste20-like kinases are involved in a variety of cellular processes which include gene transcription, stress responses, cytoskeletal organization and apoptosis. In response to apoptotic signals, MST3/STK24 is cleaved by caspase-3 and mediates apoptosis. The biological functions of MST3/STK24 are not well understood.
Description (Vector)
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 (PubMed 10644707)).(supplied by OMIM, Mar 2008)
Gene ID
8428
Gene Name (eCommerce)
serine/threonine kinase 24
Gene Name (Vector)
serine/threonine kinase 24
Gene Symbol
STK24
HGNC ID
HGNC:11403
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1296
ORF Size (bp)
1296 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase 24
RefSeq ID
NM_003576
RefSeq Synonyms
NM_003576, NM_001286649, NM_001032296, BC065378, BC035578,
Research Areas
Apoptosis,Kinase/Phosphatase,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology
Species
human
Target Sentence
MST3/STK24 is a member of the sterile 20 (Ste20)-like kinase family that acts upstream of mitogen-activated protein kinase (MAPK) pathways and regulates c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). Ste20-like kinases are involved in a variety of cellular processes which include gene transcription, stress responses, cytoskeletal organization and apoptosis. In response to apoptotic signals, MST3/STK24 is cleaved by caspase-3 and mediates apoptosis. The biological functions of MST3/STK24 are not well understood.
UniGene ID
Hs.508514
UniProt ID (eCommerce)
Q9Y6E0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.