human SOX2 Over-expression AAV

Name 
AAV-h-SOX2
Cat No 
AAV-224023
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SOX2.

AAV-224023
AAV-h-SOX2

Ready-to-use AAV expressing Human SOX2 (SRY-box 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ANOP3; MCOPS3; sex determining region Y-box 2; SRY (sex determining region Y)-box 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2
Description (eCommerce)
SRY (sex determining region Y)- box 2 (SOX2) is a transcription factor involved in embryonic development and is critical to embryonic stem cell pluripotency. Mutations in the SOX2 gene are associated with microphthalmia syndromic type 3 (MCOPS3) a condition characterized by microphthalmia or anophthalmia.
Description (Vector)
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Gene ID
6657
Gene Name (eCommerce)
SRY-box 2
Gene Name (Vector)
SRY-box 2
Gene Symbol
SOX2
HGNC ID
HGNC:11195
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
954
Protein Name (eCommerce)
Transcription factor SOX-2
RefSeq ID
NM_003106
RefSeq Synonyms
NM_003106, BC013923,
Research Areas
Brain Development,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Gene Expression,Hippo Signaling,MAPK Signaling,Neurobiology,Neurodevelopment,Notch Signaling,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology,cardiovascular,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,signal_transduction,neurobiology,developmental_biology,signal_transduction,genetics,transcription_translation,signal_transduction,developmental_biology
Species
human
Target Sentence
SRY (sex determining region Y)- box 2 (SOX2) is a transcription factor involved in embryonic development and is critical to embryonic stem cell pluripotency. Mutations in the SOX2 gene are associated with microphthalmia syndromic type 3 (MCOPS3) a condition characterized by microphthalmia or anophthalmia.
UniGene ID
Hs.518438
UniProt ID (eCommerce)
P48431

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.