human SIK2 Over-expression AAV

Name 
AAV-h-SIK2
Cat No 
AAV-222999
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SIK2.

AAV-222999
AAV-h-SIK2

Ready-to-use AAV expressing Human SIK2 (salt inducible kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LOH11CR1I; QIK; qin-induced kinase; Salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SIK2; serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SNF1-like kinase 2; SNF1LK2
Description (eCommerce)
Salt-inducible protein kinase 2 (SIK2) phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Sik2 inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0K1].
Gene ID
23235
Gene Name (eCommerce)
salt inducible kinase 2
Gene Name (Vector)
salt inducible kinase 2
Gene Symbol
SIK2
HGNC ID
HGNC:21680
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2781
ORF Size (bp)
2781 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase SIK2
RefSeq ID
NM_015191
RefSeq Synonyms
NM_015191, BC117183, BC113459,
Research Areas
Golgi Apparatus,Insulin Signaling,Kinase/Phosphatase,LKB1 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
Salt-inducible protein kinase 2 (SIK2) phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Sik2 inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0K1].
UniGene ID
Hs.269128
UniProt ID (eCommerce)
Q9H0K1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.