human SH3PXD2B Over-expression AAV
This is an AAV expressing Human SH3PXD2B.
AAV-222913
AAV-h-SH3PXD2B
Ready-to-use AAV expressing Human SH3PXD2B (SH3 and PX domains 2B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
adapter protein HOFI; adaptor protein HOFI; factor for adipocyte differentiation 49; FAD49; FTHS; HOFI; KIAA1295; SH3 and PX domain-containing protein 2B; TKS4; TSK4; tyrosine kinase substrate with four SH3 domains
Description (eCommerce)
TKS4 (tyrosine kinase substrate with four SH4 domains), also known as SH3 and PX domain-containing protein 2B (SH3PXD2B), is an adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. TKS4 binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. TKS4 plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ A1X283].
Description (Vector)
SH3PXD2B encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome.
Gene ID
285590
Gene Name (eCommerce)
SH3 and PX domains 2B
Gene Name (Vector)
SH3 and PX domains 2B
Gene Symbol
SH3PXD2B
HGNC ID
HGNC:29242
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2733
ORF Size (bp)
2733 bp
Protein Name (eCommerce)
SH3 and PX domain-containing protein 2B
RefSeq ID
NM_001017995
RefSeq Synonyms
NM_001308175, NM_001017995, BC157116, BC156242,
Research Areas
Cardiac Development,Cardiology,Cardiovascular
Research Areas (Faceted)
cardiovascular,developmental_biology
Species
human
Target Sentence
TKS4 (tyrosine kinase substrate with four SH4 domains), also known as SH3 and PX domain-containing protein 2B (SH3PXD2B), is an adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. TKS4 binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. TKS4 plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ A1X283].
UniGene ID
Hs.285666
UniProt ID (eCommerce)
A1X283
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.