human SH3PXD2B Over-expression AAV

Name 
AAV-h-SH3PXD2B
Cat No 
AAV-222913
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SH3PXD2B.

AAV-222913
AAV-h-SH3PXD2B

Ready-to-use AAV expressing Human SH3PXD2B (SH3 and PX domains 2B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
adapter protein HOFI; adaptor protein HOFI; factor for adipocyte differentiation 49; FAD49; FTHS; HOFI; KIAA1295; SH3 and PX domain-containing protein 2B; TKS4; TSK4; tyrosine kinase substrate with four SH3 domains
Description (eCommerce)
TKS4 (tyrosine kinase substrate with four SH4 domains), also known as SH3 and PX domain-containing protein 2B (SH3PXD2B), is an adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. TKS4 binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. TKS4 plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ A1X283].
Description (Vector)
SH3PXD2B encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome.
Gene ID
285590
Gene Name (eCommerce)
SH3 and PX domains 2B
Gene Name (Vector)
SH3 and PX domains 2B
Gene Symbol
SH3PXD2B
HGNC ID
HGNC:29242
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2733
ORF Size (bp)
2733 bp
Protein Name (eCommerce)
SH3 and PX domain-containing protein 2B
RefSeq ID
NM_001017995
RefSeq Synonyms
NM_001308175, NM_001017995, BC157116, BC156242,
Research Areas
Cardiac Development,Cardiology,Cardiovascular
Research Areas (Faceted)
cardiovascular,developmental_biology
Species
human
Target Sentence
TKS4 (tyrosine kinase substrate with four SH4 domains), also known as SH3 and PX domain-containing protein 2B (SH3PXD2B), is an adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. TKS4 binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. TKS4 plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ A1X283].
UniGene ID
Hs.285666
UniProt ID (eCommerce)
A1X283

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.