human SELPLG Over-expression AAV

Name 
AAV-h-SELPLG
Cat No 
AAV-222525
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human SELPLG.

AAV-222525
AAV-h-SELPLG

Ready-to-use AAV expressing Human SELPLG (selectin P ligand). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD162; CLA; PSGL-1; PSGL1
Description (Vector)
SELPLG encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
Gene ID
6404
Gene Name (Vector)
selectin P ligand
Gene Symbol
SELPLG
HGNC ID
HGNC:10722
ORF Size (aa)
1209
ORF Size (bp)
1209 bp
RefSeq ID
NM_003006
RefSeq Synonyms
NM_003006, NM_001206609, BC029782,
Species
human
UniGene ID
Hs.591014

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.