human SELPLG shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SELPLG.
shAAV-222525
AAV-h-SELPLG-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SELPLG (selectin P ligand). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD162; CLA; PSGL-1; PSGL1
Description (Vector)
SELPLG encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
Gene ID
6404
Gene Name (Vector)
selectin P ligand
Gene Symbol
SELPLG
HGNC ID
HGNC:10722
ORF Size (aa)
1209
ORF Size (bp)
1209 bp
RefSeq ID
NM_003006
RefSeq Synonyms
NM_003006, NM_001206609, BC029782,
Species
human
UniGene ID
Hs.591014
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.