human ROR1 Over-expression AAV

Name
AAV-h-ROR1

Cat No
AAV-221489

Availability
4-5 weeks

This is an AAV expressing Human ROR1.

AAV-221489

AAV-h-ROR1

Ready-to-use AAV expressing Human ROR1 (receptor tyrosine kinase like orphan receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

dJ537F10.1; NTRKR1

Description (Vector)

ROR1 encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. ROR1 is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

4919

Gene Name (Vector)

receptor tyrosine kinase like orphan receptor 1

Gene Symbol

ROR1

HGNC ID

HGNC:10256

ORF Size (aa)

2811

ORF Size (bp)

2811 bp

RefSeq ID

NM_005012

RefSeq Synonyms

NM_005012, NM_001083592, BC172555, BC156511,

Species

human

UniGene ID

Hs.654491

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.