human RGS18 Over-expression AAV

Name 
AAV-h-RGS18
Cat No 
AAV-221117
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RGS18.

AAV-221117
AAV-h-RGS18

Ready-to-use AAV expressing Human RGS18 (regulator of G-protein signaling 18). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
RGS13
Description (Vector)
RGS18 encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Gene ID
64407
Gene Name (Vector)
regulator of G-protein signaling 18
Gene Symbol
RGS18
HGNC ID
HGNC:14261
ORF Size (aa)
708
RefSeq ID
NM_130782
RefSeq Synonyms
NM_130782, BC020632,
Species
human
UniGene ID
Hs.440890

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.