human RGS18 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RGS18.
shAAV-221117
AAV-h-RGS18-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RGS18 (regulator of G-protein signaling 18). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
RGS13
Description (Vector)
RGS18 encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Gene ID
64407
Gene Name (Vector)
regulator of G-protein signaling 18
Gene Symbol
RGS18
HGNC ID
HGNC:14261
ORF Size (aa)
708
RefSeq ID
NM_130782
RefSeq Synonyms
NM_130782, BC020632,
Species
human
UniGene ID
Hs.440890
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.