human PROZ Over-expression AAV

Name
AAV-h-PROZ

Cat No
AAV-219944

Availability
4-5 weeks

This is an AAV expressing Human PROZ.

AAV-219944

AAV-h-PROZ

Ready-to-use AAV expressing Human PROZ (protein Z, vitamin K dependent plasma glycoprotein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Description (Vector)

PROZ encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.

Gene ID

8858

Gene Name (Vector)

protein Z, vitamin K dependent plasma glycoprotein

Gene Symbol

PROZ

HGNC ID

HGNC:9460

ORF Size (aa)

1203

ORF Size (bp)

1203 bp

RefSeq ID

NM_003891

RefSeq Synonyms

NM_003891, NM_001256134, BC074907, BC074906,

Species

human

UniGene ID

Hs.1011

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.