AAV with TBG promoter driven EGFP
This AAV expresses EGFP driven by a liver TBG promoter.
TBG is a 0.8kb hybrid promoter based on the human thyroid hormone-binding globulin (TBG) promoter and microglobin/bikunin enhancer. This hybrid promoter has been used for liver-specific transgene expression.
EGFP is derived from the Aequorea GFP with a Excitation/Emission spectrum around 488nm/507nm. It is the most commonly used imaging probe. Other fluorescent proteins with similar emission spectrums are Emerald, and T-Sapphire.
VB1743
AAV-TBG-EGFP
Ready-to-use AAV expressing EGFP driven by a liver TBG promoter. Available in AAV1, AAV2, AAV5, AAV6, AAV8, AAV9, AAV-DJ and other serotypes.
Related Citations
- Tetracycline Antibiotics Induce Host-Dependent Disease Tolerance to Infection. HG Colaço, etc, (2020), Immunity
- BRD7 deficiency leads to the development of obesity and hyperglycemia. JM Lee, etc, (2019), Scientific Reports
- MicroRNA-210 promotes bile acid-induced cholestatic liver injury by targeting mixed-lineage leukemia-4 methyltransferase in mice. YC Kim, etc, (2019), Hepatology
- Autophagy maintains tumour growth through circulating arginine. L Poillet-Perez, etc, (2018), Nature
- Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid ß-oxidation. S Seok, etc, (2018), JCI
- MicroRNA-378 is involved in hedgehog-driven epithelial-to-mesenchymal transition in hepatocytes of regenerating liver. J Kim, etc, (2018), Cell Death & Disease
- ALOXE3 is a hepatic fasting-responsive lipoxygenase that enhances insulin sensitivity via hepatic PPARg. CB Higgins, etc, (2018), bioRxiv
- Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPAR¿. CB Higgins, etc, (2018), JCI Insight
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.