rat WWP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Wwp1.
shADV-294661
Ad-r-WWP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Wwp1 (WW domain containing E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
Gene ID
297930
Gene Name (Vector)
WW domain containing E3 ubiquitin protein ligase 1
Gene Symbol
Wwp1
ORF Size (aa)
2757
ORF Size (bp)
2757 bp
RefSeq ID
NM_001024757
RefSeq Synonyms
NM_001024757, BC097386,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.