mouse SIRT6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Sirt6.
shADV-279532
Ad-m-SIRT6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Sirt6 (sirtuin 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2810449N18Rik; AI043036; Sir2l6
Description (Vector)
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Gene ID
50721
Gene Name (Vector)
sirtuin 6
Gene Symbol
Sirt6
ORF Size (aa)
1005
ORF Size (bp)
1005 bp
RefSeq ID
NM_181586
RefSeq Synonyms
NM_181586, NM_001163430, BC052763,
Species
mouse
UniGene ID
Mm.25643
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.