mouse VCP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Vcp.
shADV-278188
Ad-m-VCP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Vcp (valosin containing protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3110001E05; CDC48; p97; p97/VCP
Description (Vector)
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR.
Gene ID
269523
Gene Name (Vector)
valosin containing protein
Gene Symbol
Vcp
ORF Size (aa)
2421
ORF Size (bp)
2421 bp
RefSeq ID
NM_009503
RefSeq Synonyms
NM_009503, BC049114, BC043053,
Species
mouse
UniGene ID
Mm.262053
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.