mouse RAC1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rac1.
shADV-277607
Ad-m-RAC1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rac1 (RAS-related C3 botulinum substrate 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AL023026; D5Ertd559e
Description (Vector)
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts|Function: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
Gene ID
19353
Gene Name (Vector)
RAS-related C3 botulinum substrate 1
Gene Symbol
Rac1
ORF Size (aa)
579
RefSeq ID
NM_009007
RefSeq Synonyms
NM_009007, NM_001347530, BC051053, BC003828,
Species
mouse
UniGene ID
Mm.292510
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.