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mouse TNFRSF4 shRNA silencing Adenovirus

Name 
Ad-m-TNFRSF4-shRNA
Cat No 
shADV-274716
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Tnfrsf4.

shADV-274716
Ad-m-TNFRSF4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Tnfrsf4 (tumor necrosis factor receptor superfamily, member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ACT35;CD antigen CD134;CD134;Ly-70;Ox40;OX40 antigen;OX40L receptor;tax-transcriptionally activated glycoprotein 1;tumor necrosis factor receptor superfamily member 4;Txgp1;TXGP1L
Description (eCommerce)
OX40/CD134 is a member of the TNF-receptor superfamily that has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested OX40/CD134 plays a role in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [taken from NCBI Entrez Gene (Gene ID: 3659)].
Description (Vector)
Receptor for TNFSF4/OX40L/GP34.
Gene ID
22163
Gene Name (eCommerce)
tumor necrosis factor receptor superfamily, member 4
Gene Name (Vector)
tumor necrosis factor receptor superfamily, member 4
Gene Symbol
Tnfrsf4
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
819
Protein Name (eCommerce)
Tumor necrosis factor receptor superfamily member 4
RefSeq ID
NM_011659
RefSeq Synonyms
NM_011659, BC139266, BC139239,
Research Areas
Apoptosis,Cancer,Immune cells & tumor markers,Immune-checkpoints,Immunology,Immuno-Oncology,Signal Transduction,T cell markers,T Cell Receptor Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,immuno_oncology,signal_transduction
Species
mouse
Target Sentence
OX40/CD134 is a member of the TNF-receptor superfamily that has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested OX40/CD134 plays a role in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [taken from NCBI Entrez Gene (Gene ID: 3659)].
UniGene ID
Mm.13885
UniProt ID (eCommerce)
P47741

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.