mouse THOC1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Thoc1.
shADV-274162
Ad-m-THOC1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Thoc1 (THO complex 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3110002N20Rik; AW107452; NMP-84
Description (Vector)
Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4|Function: Regulates transcriptional elongation of a subset of genes. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.
Gene ID
225160
Gene Name (Vector)
THO complex 1
Gene Symbol
Thoc1
ORF Size (aa)
1974
ORF Size (bp)
1974 bp
RefSeq ID
NM_153552
RefSeq Synonyms
NM_153552, BC024951,
Species
mouse
UniGene ID
Mm.219648
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.