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mouse TCF7 shRNA silencing Adenovirus

Name 
Ad-m-TCF7-shRNA
Cat No 
shADV-273923
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Tcf7.

shADV-273923
Ad-m-TCF7-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Tcf7 (transcription factor 7, T cell specific). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AI465550; TCF-1; Tcf1
Description (Vector)
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
Gene ID
21414
Gene Name (Vector)
transcription factor 7, T cell specific
Gene Symbol
Tcf7
ORF Size (aa)
1005
RefSeq ID
NM_009331
RefSeq Synonyms
NM_009331, NM_001313981, BC145343, BC138596,
Species
mouse
UniGene ID
Mm.31630

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.