mouse STAT1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Stat1.
shADV-273293
Ad-m-STAT1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Stat1 (signal transducer and activator of transcription 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2010005J02Rik; AA408197
Description (Vector)
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Gene ID
20846
Gene Name (Vector)
signal transducer and activator of transcription 1
Gene Symbol
Stat1
ORF Size (aa)
2139
ORF Size (bp)
2139 bp
RefSeq ID
NM_009283
RefSeq Synonyms
NM_009283, NM_001205314, NM_001205313, BC004808,
Species
mouse
UniGene ID
Mm.277406
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.