mouse SOCS5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Socs5.
shADV-272836
Ad-m-SOCS5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Socs5 (suppressor of cytokine signaling 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1810018L08Rik; Cish5; mKIAA0671
Description (Vector)
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Gene ID
56468
Gene Name (Vector)
suppressor of cytokine signaling 5
Gene Symbol
Socs5
ORF Size (aa)
1611
ORF Size (bp)
1611 bp
RefSeq ID
NM_019654
RefSeq Synonyms
NM_019654, BC053015,
Species
mouse
UniGene ID
Mm.126885
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.