mouse SEPT2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Sept2.
shADV-271630
Ad-m-SEPT2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Sept2 (septin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW208991; mKIAA0158; Nedd-5; Nedd5
Description (Vector)
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
Gene ID
18000
Gene Name (Vector)
septin 2
Gene Symbol
2-Sep
ORF Size (aa)
1086
ORF Size (bp)
1086 bp
RefSeq ID
NM_010891
RefSeq Synonyms
NM_010891, NM_001159719, NM_001159718, NM_001159717, BC138637, BC138636,
Species
mouse
UniGene ID
Mm.428652
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.