human SEPT2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SEPT2.
shAAV-222604
AAV-h-SEPT2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SEPT2 (septin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DIFF6; epididymis secretory sperm binding protein; hNedd5; NEDD5; NEDD-5; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated 5; Pnutl3; septin-2
Description (eCommerce)
Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15019].
Gene ID
4735
Gene Name (eCommerce)
septin 2
Gene Name (Vector)
septin 2
Gene Symbol
2-Sep
HGNC ID
HGNC:7729
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1086
ORF Size (bp)
1086 bp
Protein Name (eCommerce)
Septin-2
RefSeq ID
NM_004404
RefSeq Synonyms
NM_006155, NM_004404, NM_001321035, NM_001321034, NM_001321033, NM_001321032, NM_001321031, NM_001321030, NM_001321029, NM_001282973, NM_001282972, NM_001008492, NM_001008491, BC033559, BC014455,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,neurobiology
Species
human
Target Sentence
Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15019].
UniGene ID
Hs.716403
UniProt ID (eCommerce)
Q15019
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.